Glucose?regulated protein ( <scp>GRP78</scp> ) is an important cell surface receptor for viral invasion, cancers, and neurological disorders

The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum (ER)-resident molecular chaperone. GRP78 a member of the 70 heat shock family proteins involved in correcting and clearing misfolded ER. In response to cellular stress, escapes from ER moves plasma membrane where it (a) functions as receptor for many ligands, (b) behaves autoantigen autoantibodies that contribute human disease cancer. Cell surface (csGRP78) associates with major histocompatibility complex class I (MHC-I), port entry several viruses, including predictive binding novel SARS-CoV-2. Furthermore, csGRP78 found association partners diverse teratocarcinoma-derived growth factor 1 (Cripto), melanocortin-4 (MC4R) DnaJ-like MTJ-1. CsGRP78 also serves large variety ligands activated ?2 -macroglobulin (?2 M*), plasminogen kringle 5 (K5), microplasminogen, voltage-dependent anion channel (VDAC), tissue (TF), prostate apoptosis response-4 (Par-4). this review, we discuss mechanisms translocation cell surface, role secreted its cancer neurological disorders.